Patients in the control arm were treated with up to four cycles of chemotherapy and optional pemetrexed maintenance (if eligible) until disease progression or toxicity. Patients in the experimental arm were treated for up to two years or until disease progression or unacceptable toxicity. The company will complete a full evaluation of the CheckMate -9LA data and looks forward to presenting these results at an upcoming congress and sharing them with regulatory authorities.ĬheckMate -9LA is an open-label, multi-center, randomized phase 3 trial evaluating Opdivo (360 mg Q3W) plus Yervoy (1 mg/kg Q6W) combined with chemotherapy (two cycles) compared to chemotherapy alone (up to four cycles followed by optional pemetrexed maintenance therapy if eligible) as a first-line treatment in patients with advanced NSCLC regardless of PD-L1 expression and histology. “These results build on the benefit the combination of Opdivo plus Yervoy has previously shown in first-line melanoma, renal cell carcinoma and most recently lung cancer, and may provide a new therapeutic option for patients.” “We are excited by the CheckMate -9LA results, which demonstrate the potential of Opdivo plus low-dose Yervoy to provide a survival benefit to patients with non-small cell lung cancer in the first-line setting when administered concomitantly with a limited course of chemotherapy,” said Fouad Namouni, M.D., head, Oncology Development, Bristol-Myers Squibb. The safety profile of Opdivo plus low-dose Yervoy and two cycles of chemotherapy in CheckMate -9LA was reflective of the known safety profiles of the immunotherapy and chemotherapy components in first-line NSCLC. The comparator in this study was chemotherapy alone for up to four cycles followed by optional maintenance therapy. PRINCETON, N.J.-( BUSINESS WIRE)- Bristol-Myers Squibb Company (NYSE: BMY) today announced that CheckMate -9LA, a pivotal Phase 3 trial evaluating Opdivo (nivolumab) plus low-dose Yervoy (ipilimumab) given concomitantly with two cycles of chemotherapy for the first-line treatment of advanced non-small cell lung cancer (NSCLC), met its primary endpoint of superior overall survival (OS) at a pre-specified interim analysis.
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NASA Glenn Research Center specializes in developing technology for aeronautics and space, including communications, propulsion, biomedical, and more.NASA Langley Research Center specializes in aviation, Earth's atmosphere, and technology.It's also home of the Scientific Visualization Studio, who has its own 360 and planetarium content. NASA Goddard Space Flight Center specializes in space telescopes, solar missions, and test chambers.NASA Ames Research Center specializes in information technology, aerospace, and aeronautics.NASA Johnson Space Center specializes in human exploration and operations.NASA Kennedy Space Center specializes in launching space missions.NASA Marshall Space Flight Center specializes in rocket engines and human spaceflight assembly.NASA Jet Propulsion Laboratory specializes in robotic space and Earth exploration, and is home to the Deep Space Network.Also, NASA’s Artemis I Rocket at Rollout, downloadable here. Latest addition: From NASA Kennedy, Orion in 360 Degrees video with downloadable stills here, here, and here. See the NASA Media Use Policy and the JPL Image Use Policy. Files are downloadable below, including videos. There are also some true, interactive VR experiences listed on this page. The media here should be usable by most digital planetarium systems, headset Virtual Reality, and smartphone VR setups, with minimum extra work to import them. Members can access an interactive, planetarium curriculum using these assets. This is a collection of media and tools, which includes 360 spherical images/videos using equirectangular warping. Software: Digital Sky 2 buttons, Uniview instructions, Digistar instructions, Digitalis instructions, Emerald Planetarium instructions, Shira player instructions, ePlanetarium instructions, OpenSpace instructions, some Rift, some Vive, and general media Format: Live, interactive, and short clips/stills, with some fully immersive Virtual Reality (VR) experiences, and some Augmented Reality (AR) experiences Next Level Racing GT Lite Foldable Simulator Cockpit.Next Level Racing GTTrack Simulator Cockpit.So, the best racing simulator seats and cockpits are: Now that you know what to look for, let’s dive right into my list of the best gaming seat racing chairs in 2023. All the features you’d look for in a regular racing cockpit.Affordability (motion cockpits can be very expensive).Full motion, including tilt, turn, and movement.Adjustable wheel support (height, tilt, distance).Good build quality (durable materials and strong frame).Included accessories/hardware (seat, shifter, wheel, pedals, etc.).High-quality upholstery and build materials.Highly adjustable (height, tilt, armrests, etc.).Once you’ve decided which type of racing simulator seat you’d like to buy and are ready to start shopping around, here’s what you should look out for: What to Look For in a Racing-style Gaming Chair: These types of racing simulator seats are the most expensive. So much so that you’ll feel as if you’re in a real car. It takes the whole experience to the next level, blurring the lines between reality and the game. This means the seat literally moves based on what’s happening in the game. Motion Cockpits are – yep, you guessed it – racing rigs that include an element of motion. Cockpits that come with their own racing seats are usually more expensive than regular racing chairs. Some cockpits come with the seat and other equipment included and attached to the frame, while others require you to purchase these extra bits separately. They enable you to create a complete set-up that fully mimics your car interior. A cockpit is essentially a metal frame on which you can mount a seat, wheel, shifter, and other racing equipment. You can pair your racing chair up with a wheel stand (which you can purchase separately) to make it more of a real racing simulator seat if you want to use a wheel rather than your controller.įull racing rigs or ‘cockpits’ are a little different. Racing-style gaming chairs are just like any other but are designed after classic racing car seats. With that in mind, there are three different types of racing simulator seat set-ups you should know about: In that case, you’ll need a racing simulator seat that comes complete with a frame to mount all those accessories on. That means a wheel, shifter, foot pedals, and various other racing sim accessories. If you want the whole shebang, you’ll need more than just the chair itself. If you just want a nice ergonomic gaming chair to sit on while you play some Forza using your regular controller, a standard racing seat will do. The first question you need to ask yourself when choosing a racing simulator seat is ‘How basic or complex do I want my setup to be?’. RESPAWN 200 Racing Style Gaming Chair, adjustable.ĭOF USB Reality Motion Simulator Platform H3 (3. Next Level Racing GT Lite Foldable Simulator. VIVO Racing Simulator Cockpit with Wheel Stand.Įxtreme Simracing Racing Simulator Cockpit With. OpenWheeler GEN3 Racing Wheel Stand Cockpit Green. Next Level Racing GTTrack Simulator Cockpit. GTR Simulator GTA Model Silver Frame with. Playseat Challenge Sim Racing Cockpit | Foldable &. Playseat Evolution Pro Sim Racing Cockpit |.
I’m not sure why, but the seat on the bike was incredibly comfortable. However my preference, and only option I wanted was the 29″ wheel, and the Incline has it! The seat Now this honestly is up to personal preference, some people my height seem to like 27.5″ wheels, while others like the 29″ wheel on their bikes. I found the rear suspension on the Incline to be perfect! I’m honestly not sure if it was just my bike, or if all of these bikes are that way, but it gave just enough, but not too much suspension in the rear.Īs I had mentioned earlier in the article, I really do like the way the Incline looks with its color scheme, frame style and overall proportions. I must say, a lot of people don’t like low end bicycles with a full suspension, as supposedly the rear shocks tend to bounce and it makes for a pogo stick affect. The price on this bike opens it up to adults who are trying to get into mountain biking, or teenagers who just went through a growth spurt (ahh the growing pains, I do remember that). I’m a big proponent that every product is meant for someone, and just because a bicycle isn’t high end doesn’t mean it isn’t great for someone to get into a new sport and upgrade as they go. It was sub $200 and offered a lot for the price, as we will talk about here in a moment. You really couldn’t go wrong with this bike’s price. There was a lot to like about the Genesis Incline, including the price, its suspension and even the styling, let’s take a look at everything more in depth here. The Aluminum frame is relatively lightweight. I like the matte black with green accents on the frame, but also green components as well. The bike also offers a full suspension, which means you have shocks in the front and rear of the bike.īraking is done by using front disc brakes and rear rim brakes, that are both wire driven. It has knobby tires, 21 gears (3 in front, 7 in back) and is over all a decent bike for the price. Our Favorite Product Price Best Overall Schwinn Boundary $$$ Best Inexpensive Genesis Incline $$ The Genesis Incline 29″ Mountain Bike However it was getting late in the year, so I wanted to bike before the snow came, so I bought it. The Genesis Incline was in stock, and ready to buy! It had many of the similar specifications, such as 29″ wheels, however was definitely not quite the quality I was looking for. So instead of continuing to hunt for a bike I likely wouldn’t get, I opted to go a different route! Setting up in-stock notifications proved to fail, as when it came back into stock online, it was immediately bought up before I could purchase. Of course, also with the pandemic going on, it also was increasingly difficult to find a mountain bike in the first place!Īfter a lot of research, I had decided on the Schwinn Boundary, however once I arrived at the store the one I had just seen there had been bought, and I was left without a bike. To set the stage, this last year I really wanted to get into Mountain Biking, however had a smaller budget, so the hunt for a budget mountain bike was started! The development of high-throughput sequencing of RNA isolated by CLIP (HITS-CLIP) has enabled a transcriptome-wide view of RNA binding sites 6. CLIP uses a limited RNase treatment of cross-linked RNPs to isolate RNA fragments occupied by the RBP and sequencing of these fragments can identify RBP binding sites, which allows inference of RBP function through determining the location of binding sites relative to, for example, other RBP binding sites or cis-acting elements (Box 1). The covalent cross-links allow stringent purification of the RNA–protein complexes, which is followed by a series of steps to determine the interactions of a specific protein across the transcriptome. CLIP techniques are more widely used and rely on the irradiation of cells by UV light, which causes proteins in the immediate vicinity of the irradiated bases to irreversibly cross-link to the RNA by a covalent bond 5 (Fig. RIP approaches purify the RNA–protein complexes under native conditions 2, 3 or using formaldehyde cross-linking 4. The most common protein-centric strategies are based on the immunopurification of an RBP and its associated RNAs, and can be broadly categorized as RNA immunoprecipitation (RIP) or cross-linking and immunoprecipitation (CLIP) approaches. These approaches can be protein-centric, describing the compendium of RNA sites bound by a specific RBP, or RNA-centric, identifying the RNA-bound proteome. Numerous methods can characterize the RNA interactions that coordinate RNP assembly. Ribonucleoprotein (RNP) complexes are key to every step of RNA processing and function, and understanding the roles that RNA-binding proteins (RBPs) play requires methods that identify the set of RNAs that they bind in cells during specific developmental stages, activities or disease states. The protein complement decorating an RNA molecule changes dynamically in space and time, orchestrating RNA processing and function in the nucleus and cytoplasm 1. Proteins begin to interact with nascent RNAs as soon as transcription is initiated. Finally, we present open questions in the field and give directions for further development and applications. We discuss the prospect of integrating data obtained by CLIP with complementary methods to gain a comprehensive view of RNP assembly and remodelling, unravel the spatial and temporal dynamics of RNPs in specific cell types and subcellular compartments and understand how defects in RNPs can lead to disease. We outline the various applications of CLIP and available databases for data sharing. We summarize the main challenges of computational CLIP data analysis, how to handle various sources of background and how to identify functionally relevant binding regions. In this Primer, we discuss the main variants of these protein-centric methods and the strategies for their optimization and quality assessment, as well as RNA-centric methods that identify the protein partners of a specific RNA. To identify the sites bound by a specific RNA-binding protein on endogenous RNAs, cross-linking and immunoprecipitation (CLIP) and complementary, proximity-based methods have been developed. Dynamic RNP assembly, largely directed by cis-acting elements on the RNA, coordinates all processes in which the RNA is involved. RNA molecules start assembling into ribonucleoprotein (RNP) complexes during transcription. If the initial break with the franchise felt jagged, Sweet D and the Suns smoothed it over. He faced demons in his personal life but fought hard to shake addiction there, too.ĭavis masked those bumps each time he stepped on the court, making the crowd go wide-eyed at that silken shot. He had faced elbow, knee and back injuries throughout his time in Phoenix. He moved from small forward to shooting guard and back again. In many ways, he made a habit out of bouncing back. Davis became a free agent and signed with the Denver Nuggets.ĭavis was known as "Greyhound" for his appearance, but also for the way he bounded up and down the court. With his contract up, the Suns were not particularly aggressive about re-signing him. The team had been shell-shocked and would garner just 28 wins. His output had dipped he was averaging just 17.9 points per game. But there was no statute of limitations on the fallout. A year later, Davis would play his last game with the franchise. He avoided jail, and his teammates avoided trial. If I'd known I was going to do that, I'd have probably gone to jail instead." "The last thing I wanted to do was get my teammates and friends indicted. I had to answer their questions," he told Sports Illustrated's Armen Keteyian in 1987. It begot a different nickname, one that Davis would probably like to smooth over: Waltergate. In 1987, Davis ended up testifying against teammates in exchange for immunity. The team as a whole found itself in the middle of a drug scandal that rocked the league. As he tried to steer his personal life back on track, his game was affected. In the 1980s, Davis was dealing with cocaine addiction, entering rehab twice. But life is messy, and Davis’ relationship with the Suns got rocky. "Sweet D" was a testament to his lock-down defense, but also his glossy movements that carried him across the court.Īll of his nicknames went back to that same smooth nature. Smith also coached Davis on the 1976 Olympic men's basketball team, which captured gold in Montreal. The Sweet D moniker started during his Chapel Hill days, where he played under coaching legend Dean Smith. In total, he received All-Star nods six times, all while playing in the Valley of the Sun. He was named an All-Star in each of his first four seasons, helping Phoenix return to the playoffs each of the next eight years. "Walter was one of the great shooters in NBA history." The Splash Brothers (Stephen Curry and Klay Thompson, too.). "I don't remember a sweeter shot," former teammate and fellow Suns Ring of Honor member Alvan Adams told NBA.com. "Ray Allen's got a great shot. In his time in Phoenix, he averaged 20.5 points per contest while using hovering around 30 minutes a game. He also had a career shooting percentage of 51.1, despite attacking from the perimeter.Īt one point, Davis held the record for most total points scored without a miss, 34. After all, you don’t have the masses herald your velvet touch without a silky smooth jumper.Īt 6-feet-6 but a lean 193 pounds, his style of play was defined by his effortless elegance. It wasn’t just that the shots fell it was how pretty they looked along the way. Davis averaged 20 points or more six times in his 15-year career. He would never top those 24.2 points per game, but he came close. He did all this in front of record crowds the Suns averaged 11,464 fans at Veterans Memorial Coliseum.įor that, he was named the Rookie of the Year. Playing alongside Paul Westphal and Don Buse, Davis helped lead the team to 49 wins, 15 more than the previous season. I got out there at small forward and ran," Davis told ESPN in 2003.Īnd run he did. "They played exactly the same way that we did at North Carolina - fast-breaking, team basketball. He averaged 24.2 points in his rookie campaign, playing in every game but one. If the adjustment was tough, Davis certainly didn’t show it. A North Carolinian born and raised, Davis would then spend the next 11 years of his life in the desert. Davis was the fifth overall pick in the 1977 draft, with the Suns plucking him from the University of North Carolina. The points started falling fast and they started falling early. He’s the Suns’ all-time leading scorer, netting 15,666 points while suited up in purple and orange. His relationship with Phoenix was fractured at times, but his accolades are clear. Walter Davis was all of those things and much, much more. Let’s start with some of the nicknames because there were plenty. View Gallery: Phoenix Suns NBA All-Stars through the years mm?mm?mm?mm?mm?mm?mm?mm?mm?mm?mm?mm?mm?mm?mm? ylh?ylh?ylh?ylh?ylh?ylh?ylh?ylh?ylh?ylh?ylh?ylh?ylh?ylh? Bomb has been defused.
The final action is to have a maintainer do a regular merge of default For more reasons, see the bookmarks footnote 4. With bookmarks you could get trapped on a feature-head which might not be merged to default for quite some time. Note: We use feature branches to ensure that new clones start at a revision which other developers can directly use. Note: To make the final merge of your feature into default easier, you can regularly merge the default branch into the feature branch. It shows your collegues, that they no longer have to keep the feature in mind as soon as they merge the most recent changes from the default branch into their own feature branches. Note: Closing the feature branch hides that branch in the output of hg branches (except when using -closed) to make the repository state lean and simple while still keeping the feature branch information in history. Hg ci -m "merged finished feature x into default" Hg ci -close-branch -m "finished feature x" Hg ci -m "merged feature x into default"` | | summary: merged feature x into default | | summary: merged finished feature x into default The feature branch gives us changesets 9 to 13 (with 10 being an example for an unrelated intermediate commit on default). Once the feature is finished, we merge it into default. The one feature-commit shown here (x) could be an arbitrary number of commits, and as long as you stay in your branch, the development of your colleagues will not disturb your own work. Now we want to do some larger development, so we use a feature branch. Hg ci -m "merged stable into default: ready for more development" Hg ci -m "merge default into stable for release" Userfriendly, simplified release notes would be a good choice. The commit-message you use for the merge to stable will become the description for your tag, so you should choose a good description instead of "merge default into stable for release". To do a regular release, we just merge the default branch into the stable branch and tag the merge. | summary: Added tag v1 for changeset f97ea6e468a1 | | summary: merge stable into default: ready for more development | | summary: merge default into stable for release | | summary: Added tag v2 for changeset 089fb0af2801 | | | summary: merged feature x into default | | | summary: merged finished feature x into default | | summary: merged default into stable for release | | summary: merged stable into default: ready for more development So just take a glance, take in theīasic structure and then move on for the details. This is the output of a complete example run 9 of the branching model, including all complications you should ever hit. All that follows are a detailed example which goes through all actions one-by-one, adaptions to this workflow and the final summary. Hg up stable hg merge default hg ci -m "(description of the main changes since the last release)" hg tag tagname hg up default hg merge stable hg ci -m "merged stable into default: ready for more development" Hg up stable (edit) hg ci -m "message" hg up default hg merge stable hg ci -m "merge stable into default: ready for more development" Hg branch stable hg tag tagname hg up default hg merge stable hg ci -m "merge stable into default: ready for more development" create the stable branch and do the first release:.first commit: (edit) hg ci -m "message".create the repo: hg init reponame cd reponame.Hg update feature-x hg ci -close-branch -m "finished feature x" hg update default hg merge feature-x hg ci -m "merged finished feature x into default" close and merge the feature when you are done:.Hg update default hg merge feature-x hg ci -m "merged feature x into default" Hg update feature-x (edit) hg ci -m "message" Hg branch feature-x (edit) hg ci -m "message" commit changes: (edit) hg ci -m "message".Now we can look at all the actions you will ever need to do in this The books offer streamlined scheduling for several people per page, which is ideal. Recycled spiral binding lets the book wrap around for easy writing. House of Doolittle 2021 Daily Group Planner, 4-Person, Black Soft Cover, 8. A group planner manages the time and activities for up to four people. Planner includes a three-year list of common holidays and two-sided paper pocket for notes. Heavy paper cover has coordinated graphics with the inside of the book. One page per weekday spread format includes four columns, each with quarter-hourly appointment times from 8:00AM to 7:45PM, days remaining, religious and national. This daily appointment book offers an organized way to track appointments for four people every day. Monthly overviews have Sunday-through-Saturday scheduling and are tabbed to make it easy to find the month you need. Full year of planning from January to December Detailed scheduling with quarter-hourly appointments 3-year reference calendar for long-range planning. House of Doolittle (HOD28292) 4-Person Daily Group Practice Planner 8 x 11. Weekly spreads include ruled daily columns with Monday-through-Sunday scheduling. Undated daily section has space for managing tasks, goals, priorities and to. Weekly section does not have times so you can enter times or notes for things to do that day. Undated weekly section has plenty of pages for schedule, plans, goals and projects. Each monthly and weekly two-page spreads feature different wildflower illustrations, notes sections, count of days/days remaining, holidays and past and future months reference. Dated planning pages range 12 months from January to December. One-page-per-weekday format includes four columns, each with quarter-hourly appointment times from 8 AM to 7:45 PM. Quantity: Secure transaction Ships from and sold by Amazon.ca. Details Select delivery location In Stock. Monthly/Weekly Wild Flower Planner offers easy long-range planning with monthly overviews and weekly detail. Daily appointment book offers an organized way to track appointments for four people every day. Details Or fastest delivery Wednesday, October 12. General Information Manufacturer:House of Doolittle Manufacturer Part Number:28774 Manufacturer Website Address: Brand Name:House of Doolittle Product Name:Wild Flower Weekly/Monthly Planner Marketing Information: These blocks are different elements of nature, such as stones, minerals, wood or earth. In both modes, the game is all about placing and destroying blocks, being able to play in first person or third person. Adventure mode: for players that create maps for users that want to play solo or online.Spectator mode: you can fly and view the game without interacting with it, from your own point of view or from the perspective of another player or creature.Extreme mode: identical to the survival mode by much more difficult as the world will disappear if the player dies.Survival mode: here you'll face up against dangers and creatures that will force you to build shelters, armors, and weapons.Creative mode: play with unlimited resources, where you can simply spend your time exploring everything that surrounds you and building great constructions.There are two game modes to make the most of the game's features, in which you can define the difficulty of the world in which you'll play, from a more pacific version to the most conflictive one: Two game modes and an unlimited experience You only need to be bear in mind a few things: if you learn how to combine and craft your tools and resources your world will open up to unlimited possibilities. In other words, you can explore worlds generated randomly and build all sorts of constructions: from an old hut to a palace worthy of a millionaire. It has also been released on other platforms such as Windows, PS4, Xbox, iPhone, in APK format for Android (the mobile version is called Pocket Edition or PE), and on Mac, with this version that we're talking about today.Īlthough the truth is that there aren't too many differences between this Minecraft for Mac and the PC version. So now backed by a huge company, the game is at its best (although who knows if it might die of its own success, it wouldn't be the first case) and has been reinforced in different aspects. and has ended up under the control of Microsoft who paid over 2 billion dollars for its rights. This sandbox adventure and construction game with huge pixels has sold dozens of millions of copies all over the world. Its creator Markus 'Notch' Persson published it through Mojang and surely didn't expect the success it reached in a very short period of time. Developed as an indie game and released publicly in 2009, Minecraft has become a mass phenomenon. |
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